Olanzapine Form IV: Discovery of a New Polymorphic Form Enabled by Computed Crystal Energy Landscapes
نویسندگان
چکیده
منابع مشابه
The potential of computed crystal energy landscapes to aid solid-form development.
Solid-form screening to identify all solid forms of an active pharmaceutical ingredient (API) has become increasingly important in ensuring the quality by design of pharmaceutical products and their manufacturing processes. However, despite considerable enlargement of the range of techniques that have been shown capable of producing novel solid forms, it is possible that practically important f...
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Computational crystal structure prediction (CSP) methods can now be applied to the smaller pharmaceutical molecules currently in drug development. We review the recent uses of computed crystal energy landscapes for pharmaceuticals, concentrating on examples where they have been used in collaboration with industrial-style experimental solid form screening. There is a strong complementarity in ai...
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ژورنال
عنوان ژورنال: Crystal Growth & Design
سال: 2019
ISSN: 1528-7483,1528-7505
DOI: 10.1021/acs.cgd.8b01881